Blue B. Lake

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

The paper builds a cross-species single-cell multi-omics kidney atlas to identify epithelial cells as a driver of epigenetic aging in diseased kidneys.

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

The paper introduces DART-FISH, a multiplexed RNA in situ hybridization technique for high-resolution profiling of human tissues, demonstrating its application on brain and kidney samples.

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

This study maps the spatial transcriptomic landscape of the human kidney papilla in stone disease, identifying immune injury and matrix remodeling as key features.

The paper constructs a reference tissue atlas of the human kidney using multi-omics data to identify cell types, pathways, and genes across nephron segments and interstitium.

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper uses single-cell multi-omics to analyze HARs and HGEs in fetal human brain development, identifying regulatory networks and key transcription factors involved in human-specific neurodevelopment.

The paper introduces SNARE-seq, a droplet-based method for simultaneous transcriptome and chromatin accessibility profiling in single cells, and applies it to study neurogenesis in mouse cerebral cortices.

The paper develops two single-cell methods to analyze human brain cells, identifies neuronal subtypes and non-neuronal cell types, and links genetic risk factors to specific cell types.