BiophysicsMethodsPeer-reviewed
Single-Molecule Methods to Investigate Mechanisms of Transcription by RNA Polymerase of Mycobacterium tuberculosis
Wenxia Lin, Omar Herrera-Asmat, Alex Tong…·Carlos Bustamante
DOI 10.1016/j.ymeth.2026.06.008
Author
Tiantian Kong
Shenzhen UniversityORCID 0000-0001-7768-7275Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 2/yrCo-Author Collaboration Network
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Recent·Most cited
- BiophysicseLifePeer-reviewed
Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase
Omar Herrera-Asmat, Alex Tong, Wenxia Lin…·Carlos Bustamante
This study characterizes the effects of three small-molecule inhibitors on MtbRNAP transcription elongation using optical tweezers, revealing distinct inhibition mechanisms and synergistic effects.
- BiophysicsbioRxivPreprint
Pentose Sugars Encode Sequence-Dependent DNA-RNA Segregation for Programmable Engineering of Multiphase Condensates
Wei Peng Guo, Feipeng Chen, Andrew B. Kinghorn…·Ho Cheung Shum
The paper shows that a single sugar difference between DNA and RNA drives phase segregation with cationic peptides, enabling programmable synthetic condensates that mimic nuclear compartments.
2 citations