BiophysicsMethodsPeer-reviewed
Single-Molecule Methods to Investigate Mechanisms of Transcription by RNA Polymerase of Mycobacterium tuberculosis
Wenxia Lin, Omar Herrera-Asmat, Alex Tong…·Carlos Bustamante
DOI 10.1016/j.ymeth.2026.06.008
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QB3ORCID 0000-0002-7965-444XUnclaimed ORCID profile · follow to get notified of new preprints
2 papers
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Wenxia Lin, Omar Herrera-Asmat, Alex Tong…·Carlos Bustamante
Omar Herrera-Asmat, Alex Tong, Wenxia Lin…·Carlos Bustamante
This study characterizes the effects of three small-molecule inhibitors on MtbRNAP transcription elongation using optical tweezers, revealing distinct inhibition mechanisms and synergistic effects.