Author

Yuyuan Zhang

Shanghai Medical College of Fudan UniversityORCID 0000-0001-7798-0607Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Fei FengiD· 2 shared Jincun ZhaoiD· 2 shared Rong ZhangiD· 2 shared Zhichao GaoiD· 2 shared Ziqiao WangiD· 2 shared Chun LiiD· 1 shared Hui FengiD· 1 shared Jiannan CheniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMicrobiology

Fei FengORCID

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2 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedNov 18, 2025

UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN

Pengcheng Wang, Ziqiao Wang, Fei Feng…·Rong Zhang

This study identifies UHRF1 as a host factor that restricts HCoV-229E infection by epigenetically silencing its receptor APN, with age-related UHRF1 decline linked to increased viral susceptibility.

1 citation

humanbulk RNA-seq

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MicrobiologybioRxivPreprintFeb 8, 2025

Glycosylphosphatidylinositol biosynthesis restricts coronavirus infection via the regulation of LY6E

Yanlong Ma, Fei Feng, Hui Feng…·Rong Zhang

This study identifies GPI biosynthesis as a conserved host restriction factor against coronaviruses, with LY6E as a key antiviral effector.

DOI 10.1101/2025.02.08.637211

humangenetic perturbation / CRISPR

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