Molecular BiologybioRxivPreprint
Spatial Transcriptomics Analysis Uncovers ER stress in MANF-deficient Purkinje Cells Underlying Alcohol-induced Cerebellar Vulnerability in Mice
Wen Wen, Hui Li, Li-Chun Lin…·Jia Luo
This study uses spatial transcriptomics to show that MANF deficiency in Purkinje cells increases ER stress and vulnerability to alcohol-induced neurodegeneration in a sex-dependent manner in mice.