Author

Di Hu

University of IowaORCID 0000-0002-1627-014XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Assay:proteomics· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Hui LiiD· 2 shared Jia LuoiD· 2 shared Wen WeniD· 2 shared Zuohui ZhangiD· 2 shared Henry L. KeeniD· 1 shared Hong Lin· 1 shared Hong LiniD· 1 shared Li-Chun LiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersPharmacology & Toxicology

Hui LiORCID

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2 papers

Recent·Most cited

Alcohol Disrupts Neural Differentiation Through Endoplasmic Reticulum Stress and PERK Pathway Activation

Zuohui Zhang, Wen Wen, Hong Lin, Di Hu, Hui Li, Jia Luo

This study shows alcohol disrupts neural differentiation by inducing ER stress and PERK pathway activation in both in vitro and in vivo models of prenatal alcohol exposure.

Neurochemistry International · Dec 29, 2025Peer-reviewedPharmacology & Toxicology

Spatial Transcriptomics Analysis Uncovers ER stress in MANF-deficient Purkinje Cells Underlying Alcohol-induced Cerebellar Vulnerability in Mice

Wen Wen, Hui Li, Li-Chun Lin, Michael S. Chimenti, Henry L. Keen, Mariah Leidinger, Di Hu, Zuohui Zhang, Hong Lin, Jia Luo

This study uses spatial transcriptomics to show that MANF deficiency in Purkinje cells increases ER stress and vulnerability to alcohol-induced neurodegeneration in a sex-dependent manner in mice.

bioRxiv · Jun 19, 2025 · PreprintMolecular Biology