Victoria J. Wright

Antibiotic treatment of meningococcal and other sepsis causative bacteria triggers the release of histone-like proteins (HLPs) that damage the endothelium and drive coagulopathy, but these effects can be neutralized by non-anticoagulant heparins or anti-HLP antibodies.

The paper integrates multi-omics data from pediatric sepsis patients to identify a reproducible inflammatory host-response axis associated with disease severity.

The paper identifies a 5-transcript signature in blood samples that distinguishes bacterial from viral pneumonia with high accuracy.

This study stratifies Kawasaki Disease patients using transcriptomic and proteomic profiles, finding KD responses resemble bacterial infections but with distinct features suggesting alternative triggers.

The paper identifies reduced host transcriptomic signatures for tuberculosis using microarray data and validates them with digital PCR, showing high accuracy in distinguishing TB from other conditions and latent TB.