Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo
Sara Formichetti, Agnieszka Sadowska, Michela Ascolani, Julia Hansen, Kerstin Ganter, Christophe Lancrin, Neil E. Humphreys, Mathieu Boulard
This study shows that reducing OGT activity in mice causes embryonic lethality proportional to the reduction in O-GlcNAc modification, with milder reductions causing developmental delays and retrovirus activation.
PLoS Genetics · Jan 9, 2025Peer-reviewedDevelopmental Biology