Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection
Benjamin J. Broomfield, Chin Wee Tan, Raymond Z. Qin, Hanna Abberger, Brigette C. Duckworth, Carolina Alvarado, Lennard Dalit, Chee Leng Lee, Rekha Shandre Mugan, Zihnil Adha Islamy Mazrad, Hiromi Muramatsu, Liana Mackiewicz, Bailey E. Williams, Jinjin Chen, Asuka Takanashi, , Joanna R. Groom
This paper shows that temporarily blocking type I interferon during viral infection boosts CD8+ T cell memory and vaccine effectiveness by promoting TSCM cell formation.
The Journal of Experimental Medicine · Feb 5, 2025Peer-reviewedImmunology