Author

Kadamba G. Papavinasasundaram

University of Massachusetts Chan Medical SchoolORCID 0000-0001-7837-1344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 4 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Christopher M. SassettiiD· 4 shared Kenan C. MurphyiD· 3 shared Charlotte Jewell ReamesiD· 2 shared Megan K. ProulxiD· 2 shared Peter O. OluochiD· 2 shared Albel SinghiD· 1 shared Amit SinghiD· 1 shared Amitava SinhaiD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

Christopher M. SassettiORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 20, 2026

Variation in multiple classes of simple sequence repeats can alter drug susceptibility in Mycobacterium tuberculosis

Peter O. Oluoch, Michael J. Luna, Gavin Fujimori…·Christopher M. Sassetti

The paper identifies SSR INDELs in Mycobacterium tuberculosis that alter antibiotic susceptibility through phylogenomic analysis and experimental validation.

DOI 10.64898/2026.09.16.752248

experimental assaydrug response / drug discovery

𝕏 PostBluesky

MicrobiologyEMBO ReportsPeer-reviewedJun 11, 2026

VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for Mycobacterium tuberculosis Virulence

Jordan Pascoe, Jane Newcombe, Jessica Mendoza…·Dany J. V. Beste

DOI 10.1038/s44319-026-00818-0

metabolomicsexperimental assay

𝕏 PostBluesky

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedFeb 24, 2025

Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection

Peter O. Oluoch, Eun‐Ik Koh, Megan K. Proulx…·Christopher M. Sassetti

This study identifies in vivo chemical-genetic interactions in tuberculosis that reveal novel drug targets and mechanisms, showing differences from in vitro results and highlighting metabolic dependencies affecting drug efficacy.

7 citations

mouseexperimental assay

𝕏 PostBluesky

MicrobiologyeLifePeer-reviewedFeb 3, 2022

Host-pathogen genetic interactions underlie tuberculosis susceptibility

Clare M. Smith, Richard E Baker, Megan K. Proulx…·Christopher M. Sassetti

This study identifies host-pathogen genetic interactions influencing tuberculosis susceptibility using a genetically diverse mouse panel and Mtb mutants.

117 citationstop 1%

mouseexperimental assay

𝕏 PostBluesky

GeneticsmBioPeer-reviewedDec 10, 2018

ORBIT: a new paradigm for geneticengineering of mycobacterial chromosomes

Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi…·Christopher M. Sassetti

ORBIT enables high-throughput chromosomal engineering in mycobacteria without requiring custom double-stranded DNA substrates by combining recombination systems and reusable payload plasmids.

160 citationstop 5%

experimental assaygenome assembly

𝕏 PostBluesky