Author

Samantha J. Nelson

University of Massachusetts Chan Medical SchoolORCID 0000-0001-9685-9263Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1 Organism:mouse· 1

Frequent Co-Authors

Aamir MiriD· 1 shared Athma A. PaiiD· 1 shared Christina E. BaeriD· 1 shared Christopher M. SassettiiD· 1 shared Dan WangiD· 1 shared Emmanouela TsagkarakiiD· 1 shared Eraj Shafiq KhokhariD· 1 shared Erik J. SontheimeriD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Aamir MirORCID

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Author profile →

2 papers

Recent·Most cited

Precision Cas9 Genome Editing in vivo with All-in-one, Self-targeting AAV Vectors

Raed Ibraheim, Phillip W.L. Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomás Rodríguez, Suk Namkung, Samantha J. Nelson, Eraj Shafiq Khokhar, Esther Mintzer, Stacy A. Maitland, Zexiang Chen, Yueying Cao, Emmanouela Tsagkaraki, Scot A. Wolfe, , Erik J. Sontheimer

This paper develops single-AAV vectors for precise in vivo genome editing using Nme2Cas9 with HDR templates or multiple sgRNAs, showing efficacy in treating HT-I and MPS-I mouse models.

Nature Communications · Nov 1, 2021Peer-reviewedMolecular Biology

ORBIT: a new paradigm for geneticengineering of mycobacterial chromosomes

Kenan C. Murphy, Samantha J. Nelson, Subhalaxmi Nambi, Kadamba G. Papavinasasundaram, Christina E. Baer, Christopher M. Sassetti

ORBIT enables high-throughput chromosomal engineering in mycobacteria without requiring custom double-stranded DNA substrates by combining recombination systems and reusable payload plasmids.

mBio · Dec 10, 2018Peer-reviewedGenetics