Aditi D. Singh

The paper identifies ICOP1 and ICOP2 as proteins interacting with ISWI1 that are essential for chromatin remodeling and DNA elimination during somatic genome development in Paramecium.

This study investigates genome development in Loxodes magnus, finding no canonical IESs or editing hallmarks during MIC-to-MAC development, suggesting a loss or streamlining of genome editing processes.

This study identifies two paralogous PHD finger proteins, DevPF1 and DevPF2, involved in DNA elimination during genome reorganization in Paramecium tetraurelia, with distinct roles in IES excision and small RNA regulation.

The paper shows that ISWI-mediated nucleosome depletion and small RNAs are required for precise DNA elimination of transposon remnants in Paramecium.

The paper identifies an ambiguous genetic code in karyorelict ciliates, where stop codons are reassigned to amino acids, and finds this code is used across multiple families.

The paper analyzes IESs in Blepharisma stoltei, revealing MITEs as a major source of IESs and challenging current models of transposon domestication in ciliates.

The paper reports the somatic genome of Blepharisma stoltei, identifying a PiggyBac transposase homolog as a potential IES excisase, suggesting an evolutionary origin for genome editing.