Brandon Kwee Boon Seah

The paper analyzes the nuclear genomes of Mesodinium rubrum and finds it lacks spliceosomal introns and related machinery, suggesting introns hinder endosymbiotic genomic integration.

The paper examines metabolic changes in Mesodinium species, finding that increased photosynthesis leads to reduced metabolic autonomy and loss of key biosynthetic capabilities.

The paper identifies ICOP1 and ICOP2 as proteins interacting with ISWI1 that are essential for chromatin remodeling and DNA elimination during somatic genome development in Paramecium.

This study investigates genome development in Loxodes magnus, finding no canonical IESs or editing hallmarks during MIC-to-MAC development, suggesting a loss or streamlining of genome editing processes.

The paper identifies an ambiguous genetic code in karyorelict ciliates, where stop codons are reassigned to amino acids, and finds this code is used across multiple families.

The paper analyzes IESs in Blepharisma stoltei, revealing MITEs as a major source of IESs and challenging current models of transposon domestication in ciliates.

The paper reports the somatic genome of Blepharisma stoltei, identifying a PiggyBac transposase homolog as a potential IES excisase, suggesting an evolutionary origin for genome editing.

BleTIES annotates and analyzes internally eliminated sequences in ciliates using long-read sequencing data.

phyloFlash rapidly profiles and assembles SSU rRNA from metagenomes, recovering complete genomes of previously unknown taxa.