Author

Kelly McCastlain

St. Jude Children's Research HospitalORCID 0000-0001-7868-3049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Gang WuiD· 2 shared Mondira KunduiD· 2 shared Ti‐Cheng ChangiD· 2 shared Benshang Li· 1 shared Besian I. SejdiuiD· 1 shared Catherine E. WelshiD· 1 shared Charles GawadiD· 1 shared Devansh Shah· 1 shared

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2024-2025 · peak 1/yr

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10 top collaborators · 39 mutual co-author links

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2 shared papersBioinformatics

Gang WuORCID

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2 papers

Recent·Most cited

BioinformaticsComputational and Structural Biotechnology JournalPeer-reviewedJan 1, 2025

MitoEdit: a pipeline for optimizing mtDNA base editing and predicting bystander effects

Devansh Shah, Kelly McCastlain, Ti‐Cheng Chang…·Mondira Kundu

MitoEdit predicts optimal mtDNA base editing targets and bystander effects to reduce empirical testing.

1 citation

humanDNA methylation

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Genetic & Genomic MedicinemedRxivPreprintSep 26, 2024

Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cells

Kelly McCastlain, Catherine E. Welsh, Yonghui Ni…·Mondira Kundu

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.

1 citation

humanwhole-genome sequencing

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