Author

Yonghui Ni

St. Jude Children's Research HospitalORCID 0000-0002-1127-1004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Stanley B PoundsiD· 2 shared Amit BudhrajaiD· 1 shared Benshang Li· 1 shared Besian I. SejdiuiD· 1 shared Catherine E. WelshiD· 1 shared Charles GawadiD· 1 shared Dennis VoroniniD· 1 shared Dixie Brewington· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Stanley B PoundsORCID

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2 papers

Recent·Most cited

Mitochondrial Integrated Stress Response Activation Creates a Therapeutic Vulnerability to MCL-1 Inhibition in Acute Myeloid Leukemia

Lauren Brakefield, Amit Budhraja, Peter A. Hall, Dixie Brewington, Jamila Moore, Josi Lott, Yonghui Ni, Dennis Voronin, Oliver Grant-Chapman, Tresor O Mukiza, Tristen Wright, Yong‐Dong Wang, Sandi Radko-Juettner, Shondra M. Pruett‐Miller, Stanley B Pounds, , Joseph T. Opferman

This study identifies co-targeting of MCL-1 and ETC complex I as a synergistic therapy for high-risk AML, showing improved viability reduction and survival in preclinical models.

Cell Death and Disease · Jun 25, 2026Peer-reviewedCancer Biology

Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cells

Kelly McCastlain, Catherine E. Welsh, Yonghui Ni, Liang Ding, Melissa Franco, Robert J. Autry, Besian I. Sejdiu, Ti‐Cheng Chang, Wenan Chen, Huiyun Wu, Qingfei Pan, Veronica Gonzalez-Pena, Patrick A. Schreiner, Sasi Arunachalam, Joung Hyuck Joo, , Mondira Kundu

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.

medRxiv · Sep 26, 2024 · PreprintGenetic & Genomic Medicine