Mondira Kundu

The paper shows glucose starvation impairs ER-to-Golgi trafficking, reducing surface proteins like E-cadherin and promoting metastasis through AMPK and ULK1 signaling.

MitoEdit predicts optimal mtDNA base editing targets and bystander effects to reduce empirical testing.

This study shows that somatic mtDNA mutations affect metabolic plasticity in leukemia development, with heterozygous mutations supporting NMyc-driven leukemia while homozygous mutations impair it.

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.