Ti‐Cheng Chang

Chemokine-Dependent Natural Killer Cells Prevent Pulmonary Metastasis in a Newly Established Mouse Osteosarcoma Model

This study identifies CCL2 as a chemokine that limits osteosarcoma metastasis via NK cell signaling in a mouse model.

Megabase-scale loss of heterozygosity provoked by CRISPR-Cas9 DNA double-strand breaks

This study investigates LOH caused by CRISPR-Cas9 DSBs, showing large-scale loss and mechanisms, and highlights risks when combined with end joining inhibition.

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL

This study identifies uridine metabolism as a therapeutic target for chemo-resistant B-ALL by linking active signaling to uridine dependency and demonstrating DHODH inhibition as a promising treatment.

MitoEdit: a pipeline for optimizing mtDNA base editing and predicting bystander effects

MitoEdit predicts optimal mtDNA base editing targets and bystander effects to reduce empirical testing.

Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cells

The paper identifies differences in mtDNA mutation accumulation and selective pressures in pediatric leukemias using bulk and single-cell sequencing, linking these to functional heterogeneity among leukemic cells.

Preclinical Pediatric Molecular Analysis for Therapy Choice (MATCH)

This paper establishes a diverse collection of preclinical models for pediatric solid tumors and demonstrates their utility in precision medicine trials and drug testing.