Pharmacology & ToxicologybioRxivPreprint
Cellular thermal shift assay of subcellular isolates for evaluating drug-membrane target interactions
Sahiba K. Dogra, Varunya M. Kattunga, Shona A. Mookerjee…·Julie Kay Andersen
This paper applies CETSA to isolated mitochondria to study drug-membrane target interactions, showing that mitochondrial isolation preserves drug-target binding that is lost in whole cells or lysates.
DOI 10.64898/2026.02.03.703651