Julie Kay Andersen

Advanced Open-Source Experimental-Design Tools for Microplate-Based Assays with Acoustic Liquid Handling

The paper introduces PickliPy, an open-source framework for converting assay designs into ADE picklists, enabling reproducible and scalable microplate-based experiments.

Mitochondrial Hsp60/10 Client Protein Decline Reveals Braak/Tau- and Cognition-Linked Proteostasis Vulnerabilities in Alzheimer's Disease

The paper evaluates Hsp60/10 client proteins in Alzheimer's disease, finding their decline correlates with proteostasis vulnerabilities, Braak/tau burden, and cognitive impairment.

In vitro comparison of Aβ-targeting SNIPR, synNotch, and TRUCK for cell-based drug delivery in Alzheimer's disease.

The paper compares SNIPR, synNotch, and TRUCK systems for Aβ-targeting cell-based drug delivery in Alzheimer's disease, finding SNIPR and synNotch outperform TRUCK in therapeutic response.

Coordination of Anle138b to Silver Results in Selective Reduction of a C-terminal truncated Alpha-synuclein Protein and Increased Aggregate Size

The paper investigates how Anle138b coordination with silver affects alpha-synuclein aggregation, showing reduced C-terminal truncation and increased aggregate size.

Shifts in protein aggregate stability define proteostasis decline in the aging human brain

This study shows that human brain aging involves asymmetric remodeling of the insoluble proteome, with intermediate-stability aggregates accumulating and being linked to neurodegenerative disease.

A Compound Enhancing Lysosomal Function Reduces Tau Pathology, Microglial Reactivity and Rescues Working Memory in 3xTg AD Mice

This study evaluates a natural compound (MIC) that reduces tau pathology and microglial reactivity in 3xTgAD mice and rescues working memory, suggesting it as a potential therapeutic for Alzheimer's disease.

Single-Cell Spatial Proteomics Uncovers Molecular Interconnectivity among Hallmarks of Aging

The paper uses single-cell spatial proteomics in yeast to uncover molecular changes linked to aging hallmarks and their spatial organization.

Cellular thermal shift assay of subcellular isolates for evaluating drug-membrane target interactions

This paper applies CETSA to isolated mitochondria to study drug-membrane target interactions, showing that mitochondrial isolation preserves drug-target binding that is lost in whole cells or lysates.

Aβ-targeting synNotch Receptor for Alzheimer's Disease: Expanding Applications to Extracellular Protein Aggregates

This paper demonstrates that a synNotch receptor can target extracellular Aβ aggregates, enabling the production of AD therapies like Lecanemab and Aducanumab in response to these aggregates.

Mitigating Proinflammatory SASP and DAMP with Urolithin A: A Novel Senomorphic Strategy

This study shows that Urolithin A reduces pro-inflammatory SASP and DAMP factors by inhibiting cytosolic DNA release and cGAS-STING signaling.

A Human Neuron Alzheimer's Disease Model Reveals Barriers to Senolytic Translatability

The paper evaluates senolytic therapies in a human neuron AD model, finding Navitoclax's neurotoxicity and NK92's preferential targeting of senescent-like cells.

Chimeric Antigen Receptors Discriminate Between Tau and Distinct Amyloid-Beta Species

The paper demonstrates that CARs based on AD antibodies can detect and discriminate between tau and distinct Aβ species, suggesting their potential for targeted AD therapies.

Amyloid β accelerates age-related proteome-wide protein insolubility.

This study shows that amyloid β accelerates age-related protein insolubility in C. elegans and links this process to neurodegenerative and age-related diseases through proteomics and GWAS.

Neuronal expression of human amyloid-β and Tau drives global phenotypic and multi-omic changes in C. elegans

This study shows that expressing human amyloid-β and Tau in C. elegans neurons causes phenotypic and multi-omic changes, including accelerated aging and metabolic dysfunction.