Anand Rane

This study evaluates a natural compound (MIC) that reduces tau pathology and microglial reactivity in 3xTgAD mice and rescues working memory, suggesting it as a potential therapeutic for Alzheimer's disease.

This paper applies CETSA to isolated mitochondria to study drug-membrane target interactions, showing that mitochondrial isolation preserves drug-target binding that is lost in whole cells or lysates.

This study shows that Urolithin A reduces pro-inflammatory SASP and DAMP factors by inhibiting cytosolic DNA release and cGAS-STING signaling.