Manish Chamoli

This study shows that human brain aging involves asymmetric remodeling of the insoluble proteome, with intermediate-stability aggregates accumulating and being linked to neurodegenerative disease.

This study evaluates a natural compound (MIC) that reduces tau pathology and microglial reactivity in 3xTgAD mice and rescues working memory, suggesting it as a potential therapeutic for Alzheimer's disease.

This paper applies CETSA to isolated mitochondria to study drug-membrane target interactions, showing that mitochondrial isolation preserves drug-target binding that is lost in whole cells or lysates.

This study shows that Urolithin A reduces pro-inflammatory SASP and DAMP factors by inhibiting cytosolic DNA release and cGAS-STING signaling.

This study identifies new kinases modulating insulin signaling and longevity in C. elegans through a kinome-wide RNAi screen, revealing correlations between thermotolerance, dauer formation, and lifespan extension.

This study shows that amyloid β accelerates age-related protein insolubility in C. elegans and links this process to neurodegenerative and age-related diseases through proteomics and GWAS.

This study identifies MG-H1 as a mediator of increased food intake in C. elegans glod-4 mutants through a tyramine signaling pathway regulated by the GATA transcription factor ELT-3.

The paper shows that FOXO/DAF-16 mediates cell non-autonomous germline quality control in response to somatic DNA damage in C. elegans, ensuring progeny fitness.