Honggui Wu

The paper uses single-cell 3D genome mapping to show cohesin-mediated loop extrusion forms transcription elongation loops that enhance transcriptional burst frequency.

The paper introduces two new methods, ChrODIE and ANDIE, for mapping chromatin accessibility and histone modifications without enzymatic cleavage, enabling multi-omics integration.

The paper generates transcriptome and 3D genome atlases of developing mouse brain cells, revealing structure-type-based cell identity and experience-independent developmental changes.

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.