José Miguel Ramírez

The paper quantifies how sex, age, genetic ancestry, and BMI influence DNA methylation across 9 tissues in 424 individuals, finding that ancestry and age have the greatest impact.

The paper integrates histological and RNA-seq data to show asynchronous aging dynamics across female reproductive organs, with menopause marking a key transition in the uterus and vagina.

This study shows that cigarette smoking causes molecular changes in tissues similar to aging, including inflammation, hypomethylation at enhancers, and hypermethylation at Polycomb target regions.

The paper introduces a method to quantify RNA modifications using nanopore sequencing, revealing novel modification sites and dynamics in yeast under environmental stress.

The paper identifies tissue- and cancer-specific RNA modification machinery (RMP) expression patterns and dysregulation across 32 tissues, 10 species, and 13,358 tumor-normal samples.

This paper demonstrates the detection of m6A RNA modifications in native RNA sequences using Oxford Nanopore Technologies with high accuracy.