Winona Oliveros

The paper quantifies how sex, age, genetic ancestry, and BMI influence DNA methylation across 9 tissues in 424 individuals, finding that ancestry and age have the greatest impact.

The paper uses long-read RNA-seq from diverse human populations to reveal ancestry bias in gene annotations and shows improved transcript discovery with personal genome assemblies.

The paper introduces rDNAcaller, a pipeline for accurate rDNA variant detection using short-read whole-genome sequencing, achieving 94% precision and identifying 5,607 novel variant positions across human populations.

This study shows that cigarette smoking causes molecular changes in tissues similar to aging, including inflammation, hypomethylation at enhancers, and hypermethylation at Polycomb target regions.

The paper compares CRISPRi perturbation screens and eQTLs in identifying target genes for GWAS-associated loci, finding they often identify distinct genes and complement each other.

The paper shows that aging leads to increased intron retention and spurious splicing, causing transcriptome deterioration across multiple human tissues.

This study uses whole-genome sequencing to identify regulatory and novel genic variants contributing to childhood cardiomyopathy.

The paper measures cis and trans effects on regulatory elements between human and mouse to show cis-trans compensation is uncommon within individual elements.