Morghan C. Lucas

Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures

The paper uses rRNA modification patterns to identify tissue and tumor-specific signatures, showing their potential as diagnostic biomarkers.

Parallel in-depth analysis of repeat expansions: an updated Clin-CATS workflow for nanopore R10 flow cells

The paper updates the Clin-CATS workflow to analyze repeat expansions using Oxford Nanopore R10 flow cells, expanding gene panels and improving detection of complex repeats.

Enhanced detection of RNA modifications and mappability with high-accuracy nanopore RNA basecalling models

This paper shows that using high-accuracy nanopore RNA basecalling models improves detection of RNA modifications, read mappability, and basecalling accuracy.

Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart

This study investigates the role of RPL3L in ribosome heterogeneity and mitochondrial activity in cardiomyocytes, finding that its depletion increases ribosome-mitochondria interactions and ATP levels.

Quantitative profiling of native RNA modifications and their dynamics using nanopore sequencing

The paper introduces a method to quantify RNA modifications using nanopore sequencing, revealing novel modification sites and dynamics in yeast under environmental stress.

Barcoding and demultiplexing Oxford Nanopore native RNA sequencing reads with deep residual learning

This paper introduces a deep learning method for barcoding and demultiplexing direct RNA sequencing reads without base-calling or additional library steps, achieving high specificity and read demultiplexing rates.

Integrative analyses of the RNA modification machinery reveal tissue- and cancer-specific signatures

The paper identifies tissue- and cancer-specific RNA modification machinery (RMP) expression patterns and dysregulation across 32 tissues, 10 species, and 13,358 tumor-normal samples.

Accurate detection of m6A RNA modifications in native RNA sequences

This paper demonstrates the detection of m6A RNA modifications in native RNA sequences using Oxford Nanopore Technologies with high accuracy.