Marta Melé

This study identifies reversible and persistent molecular changes in diet-induced obesity using multi-omic analysis, showing that microbial functional profiles drive persistent alterations.

The paper quantifies how sex, age, genetic ancestry, and BMI influence DNA methylation across 9 tissues in 424 individuals, finding that ancestry and age have the greatest impact.

The paper creates a single-cell atlas of transcript usage changes during antiviral immune responses in humans, showing lineage-specific and ancestry-related variations across influenza and SARS-CoV-2 infections.

The paper integrates histological and RNA-seq data to show asynchronous aging dynamics across female reproductive organs, with menopause marking a key transition in the uterus and vagina.

The paper performs a federated cis-eQTL meta-analysis across single-cell datasets to identify cell-type-specific genetic effects and link them to disease mechanisms.

The paper uses long-read RNA-seq from diverse human populations to reveal ancestry bias in gene annotations and shows improved transcript discovery with personal genome assemblies.

The paper introduces rDNAcaller, a pipeline for accurate rDNA variant detection using short-read whole-genome sequencing, achieving 94% precision and identifying 5,607 novel variant positions across human populations.

This study shows that cigarette smoking causes molecular changes in tissues similar to aging, including inflammation, hypomethylation at enhancers, and hypermethylation at Polycomb target regions.

This study uses single-cell RNA sequencing to analyze immune aging in 982 donors, revealing sex-specific changes in immune cell composition and function during aging.

Demuxafy improves droplet assignment and doublet removal in scRNA-seq by combining multiple demultiplexing and doublet detection methods.

The paper introduces TransCistor, a framework to identify cis-regulatory lncRNAs with controlled false discovery rates, finding that only a minority of lncRNAs are cis-acting, primarily as activators.

The paper shows that aging leads to increased intron retention and spurious splicing, causing transcriptome deterioration across multiple human tissues.

This study profiles lncRNA expression in single cells during Ebola virus infection in vivo, revealing cell-type specific changes and potential roles in immune response and viral hijacking.

The paper quantifies protein levels across 32 human tissues and compares them to transcriptome data, revealing insights into post-transcriptional regulation and disease mechanisms.

The paper measures cis and trans effects on regulatory elements between human and mouse to show cis-trans compensation is uncommon within individual elements.

The paper uses computational methods and MPRA to analyze lncRNA and mRNA promoters, finding that divergent promoters have higher transcriptional activity and lower tissue-specificity, while lincRNAs and eRNAs are more tissue-specific with simpler TF motif profiles.

The paper identifies differences in chromatin environment, transcriptional regulation, and splicing between lincRNAs and mRNAs in human cell lines.