Wilson J. Liao

This study analyzes T cell subsets, clonality, and trajectories in psoriasis using single-cell RNA and TCR sequencing, revealing tissue-specific and shared features of the T-cell repertoire.

This study identifies genetic risk factors associated with severe psoriasis and shows that polygenic risk scores can predict severe disease outcomes better than traditional risk factors.

This study performs a GWAS meta-analysis of psoriasis, identifying 109 susceptibility loci, including 45 new ones, and highlights potential therapeutic targets and disease mechanisms.

This study examines the effects of secukinumab on transcriptomic changes in psoriatic skin and T cell subsets over 12 weeks, showing significant reduction in IL17A and related genes.

MHC*IMP imputes alleles for MHC genes using a reference panel and SNP data, achieving high accuracy in allele prediction.

The paper investigates the association between LILRB2-HLA-B interaction strength and psoriasis susceptibility using GWAS data, finding an inverse relationship with risk.