Off-the-shelf allogeneic polyclonal CD38KO/CD38-CAR γδT cells for the treatment of T cell malignancies
Genesis Snyder, Alexia K. Martin, Yasemin Sezgin, Colin T. Maguire, Branden S. Moriarity, Beau R. Webber, Erin Cross, Marcelo de Souza Fernandes Pereira, Noushin Saljoughian, Ana L. Portillo, Misaal Mehboob, Justin M. Lyberger, Kevin A. Cassady, Ali A. Ashkar, Gregory K. Behbehani, , Meisam Naeimi Kararoudi
This paper develops CD38KO/CD38-CAR γδT cells for T cell malignancies, showing they effectively target T-ALL without causing fratricide or GvHD.
bioRxiv · Aug 30, 2025 · PreprintImmunology