Author

Ahmed Sadik

German Cancer Research CenterORCID 0000-0002-0328-1990Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Christiane A. OpitziD· 2 shared A. Katharina CeranskiiD· 1 shared Alessa HennebergiD· 1 shared Alina Ritter· 1 shared Ana BanitoiD· 1 shared Andreas von DeimlingiD· 1 shared Anna C. EhlersiD· 1 shared Anneliene H. Jonker· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Christiane A. OpitzORCID

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2 papers

Recent·Most cited

Dynamic oncogene activity metabolically reprograms the tryptophan-kynurenine-AHR axis driving immune evasion and tumor progression in Ewing sarcoma

Martha Julia Carreño-Gonzalez, Kimberley M. Hanssen, Ahmed Sadik, Alessa Henneberg, Maximilian M. L. Knott, Anna C. Ehlers, A. Katharina Ceranski, Zuzanna Kolodynska, Malenka Zimmermann, Roland Imle, Anneliene H. Jonker, Florian H. Geyer, Alina Ritter, Ana Banito, Clémence Henon, , Thomas G. P. Grünewald

This study shows that reduced EWSR1::ETS activity in Ewing sarcoma promotes immune evasion via the tryptophan-kynurenine-AHR axis, leading to worse clinical outcomes and tumor progression.

bioRxiv · May 16, 2025 · PreprintCancer Biology

Spatial Probabilistic Mapping of Metabolite Ensembles in Mass Spectrometry Imaging

Denis Abu Sammour, James Lucas Cairns, Tobias Boskamp, Tobias Keßler, Carina Ramallo Guevara, Verena Panitz, Ahmed Sadik, Jonas Cordes, Christian Marsching, Mirco Friedrich, Michael Platten, Ivo Wolf A, Andreas von Deimling, Christiane A. Opitz, Wolfgang Wick, Carsten Hopf

This paper introduces moleculaR, a computational framework for probabilistic mapping and statistical testing of metabolites in mass spectrometry imaging data.

bioRxiv · Oct 27, 2021 · PreprintBioinformatics