Author

Isabella Melena

Washington University in St. LouisORCID 0000-0001-7894-0682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Jing W. HughesiD· 2 shared Alexander J. PolinoiD· 1 shared Jeong Hun Jo· 1 shared Jonathan Campbell· 1 shared Lifei ZhuiD· 1 shared Samantha Adamson DiGruccio· 1 shared Sanja SvibeniD· 1 shared Shannon E. TownsendiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Jing W. HughesORCID

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2 papers

Recent·Most cited

Cell BiologyMolecular MetabolismPeer-reviewedMar 25, 2026

Primary cilia regulate GLP-1 signaling in pancreatic beta cells

Isabella Melena, Jeong Hun Jo, Shannon E. Townsend…·Jing W. Hughes

This study shows primary cilia are essential for GLP-1R signaling in pancreatic beta cells, as their loss impairs insulin secretion and cAMP/Ca2+ responses.

4 citationstop 1%

mousehuman

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Cell BiologyJournal of Cell SciencePeer-reviewedMay 28, 2024

Immuno-Scanning Electron Microscopy of Islet Primary Cilia

Sanja Sviben, Alexander J. Polino, Isabella Melena, Jing W. Hughes

This study uses immuno-SEM to identify specific proteins on primary cilia of mouse and human pancreatic islets, overcoming limitations of conventional imaging methods.

9 citations

mousehuman

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