Nacho Aguiló

This study identifies ST8SIA4-mediated polysialylation as essential for CCR2-driven monocyte egress from the bone marrow, revealing a novel regulatory mechanism in immune cell trafficking.

This study shows that intravenous BCG reduces lung metastases from bladder cancer in mice by activating NK cells, but is ineffective against established tumors due to immune evasion mechanisms.

This study shows that IV BCG reprograms monocyte/macrophage populations in mice, shifting them to pro-inflammatory phenotypes that enhance antitumor immunity by boosting NK and T cell responses.