The paper develops ImPheNet, a deep learning tool to classify phenotypes and assess drug toxicity in Dravet Syndrome brain organoids using live imaging data.

iScience · Oct 23, 2025Peer-reviewedDevelopmental Biology

MT5-MMP controls APP metabolism and the fate of beta-CTF/C99 and Abeta through proteolytic-dependent and -independent mechanisms relevant for Alzheimer's disease

Laura García‐González, Jean‐Michel Paumier, Laurence Louis, Dominika Piłat, Anne Bernard, Delphine Stephan, Nicolas Jullien, Frédéric Checler, Emmanuel Nivet, Michel Khrestchatisky, Kévin Baranger, Santiago Rivera

This study identifies MT5-MMP's role in regulating APP processing and Aβ levels through proteolytic and non-proteolytic mechanisms in Alzheimer's disease.

The FASEB Journal · Jun 12, 2021Peer-reviewedNeuroscience

The Alzheimer's disease risk factor APOE4 drives pro-inflammation in human astrocytes via HDAC-dependent repression of TAGLN3

Laurie Arnaud, Philippe D. Benech, Louise Greetham, Delphine Stephan, Angélique Jimenez, Nicolas D. Jullien, Laura García‐González, Philipp O. Tsvetkov, François Devred, Ignacio Sancho-Martinez, Juan-Carlos Izpisua Belmonte, Kévin Baranger, Santiago Rivera, Emmanuel Nivet

This study shows APOE4 promotes inflammation in human astrocytes by repressing TAGLN3 through HDAC activity, linking it to Alzheimer's disease pathology.

bioRxiv · Apr 16, 2021 · PreprintNeuroscience