Developmental BiologybioRxivPreprint
LINE1 promotes nuclear compartmentalization to repress the 8-cell state in embryonic stem cells
Juan Zhang, Lamisa Ataei, Liang Li Wu…·Miguel Ramalho‐Santos
This paper shows that LINE1 RNA is essential for maintaining hESCs by preventing the 8C state through nuclear compartmentalization and PRC2-mediated repression.
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