Jeffrey L. Wrana

The paper uses long-read RNA sequencing to identify non-coding isoform switching that regulates cell fate during reprogramming.

This study maps spatiotemporal changes in cytoskeletal and junctional protein interactions during somatic cell reprogramming using time-resolved proximity proteomics.

The paper introduces VIVOS, a 3D human vascular platform that links intraluminal flow to endothelial state transitions and vessel remodeling through YAP/TAZ-Apelin signaling.

This study shows Lgr5+ stem cells maintain intestinal epithelial homeostasis and drive regeneration after injury through WNT signaling.

This study shows PIEZO channels are essential for intestinal stem cell maintenance by sensing mechanical cues from their niche.

The paper identifies revSCs as regenerative cells in damaged intestinal crypts, showing TGFβ and Hippo pathways are critical for their function and intestinal regeneration.

This paper shows that LINE1 RNA is essential for maintaining hESCs by preventing the 8C state through nuclear compartmentalization and PRC2-mediated repression.

This study shows that bacterial ADP-heptose triggers a revival stem cell program in the intestinal epithelium by inducing Paneth cell dedifferentiation and ISC loss.

Head-to-head on serial prostate adenocarcinoma sections: Xenium gave higher sensitivity, wider dynamic range and closer agreement with snRNA-seq; CosMx segmented cells better out of the box.

This study shows fibroblast-derived exosomes promote axon outgrowth in neurons via the Wnt-PCP pathway, while neuron- or astrocyte-derived exosomes do not or inhibit this process.

The paper develops cerebral organoids from iPSCs derived from PBMCs to study mitochondrial health across stages and shows preserved mitochondrial function and treatment responses.

This study develops a robust method to produce uniform human cerebral organoids with consistent morphology and cell type composition, achieving an 80% success rate.