Daniel Trcka

Spatiotemporal remodeling of cytoskeletal and junction networks during somatic cell reprogramming

This study maps spatiotemporal changes in cytoskeletal and junctional protein interactions during somatic cell reprogramming using time-resolved proximity proteomics.

Chromatin Remodelling in Damaged Intestinal Crypts Orchestrates Redundant TGFβ and Hippo Signalling to Drive Regeneration

The paper identifies revSCs as regenerative cells in damaged intestinal crypts, showing TGFβ and Hippo pathways are critical for their function and intestinal regeneration.

LINE1 promotes nuclear compartmentalization to repress the 8-cell state in embryonic stem cells

This paper shows that LINE1 RNA is essential for maintaining hESCs by preventing the 8C state through nuclear compartmentalization and PRC2-mediated repression.

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem Cells

This study develops a robust method to produce uniform human cerebral organoids with consistent morphology and cell type composition, achieving an 80% success rate.