LINE1 promotes nuclear compartmentalization to repress the 8-cell state in embryonic stem cells
Juan Zhang, Lamisa Ataei, Liang Li Wu, Kirti Mittal, Linh Huynh, Shahil Sarajideen, Md. Abdul Mazid, David P. Cook, Daniel Trcka, Kevin Tse, Jeffrey L. Wrana, Michael M. Hoffman, Miguel Angel Esteban, Miguel Ramalho‐Santos
This paper shows that LINE1 RNA is essential for maintaining hESCs by preventing the 8C state through nuclear compartmentalization and PRC2-mediated repression.
bioRxiv · Sep 22, 2024 · PreprintDevelopmental Biology