Miguel Ramalho‐Santos

The paper identifies Nodal/Smad2 signaling as essential for sustaining embryonic diapause by repressing Pparg-mediated lipid metabolism.

The paper identifies CHD1 as a synthetic lethal target in MYC-driven breast cancer, showing that its loss suppresses tumor growth and induces cell death in MYC-overexpressing models.

The paper identifies a ligand/receptor trafficking clock in pluripotent stem cells that regulates self-renewal and abscission dynamics through cyclic turnover of Netrin-1 and its receptors.

The paper identifies alpha satellite RNA's role in marking the perinucleolar compartment and repressing rRNA expression in naive hESCs.

This paper shows that LINE1 RNA is essential for maintaining hESCs by preventing the 8C state through nuclear compartmentalization and PRC2-mediated repression.

This study identifies m6A RNA methylation by Mettl3 as essential for developmental pausing in mice by maintaining transcriptional dormancy through mRNA destabilization and suppression of N-Myc.

The paper introduces absolute scaling for single-cell RNA-seq to estimate total transcript abundances, revealing hypertranscription in adult stem and progenitor cells across multiple tissues.

This study identifies Chd1's role in repairing DNA breaks in embryonic stem cells, showing its importance in maintaining hypertranscription during development.

The paper shows that Usp9x stabilizes PRC2 to regulate H3K27me3 redistribution during mouse development, linking Usp9x to stemness and disease.

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

The paper shows that translation directly regulates chromatin state and transcription in ES cells, with reduced translation causing rapid chromatin changes.