Brian G. Ciruna

This study shows that Vangl2 in different cell types of zebrafish neuromasts contributes to bidirectional hair-bundle polarity and tissue-wide alignment, with distinct roles in hair cells and support cells.

This study uses zebrafish models to show that complement components c3 and c5 modulate spinal curve severity in a sex-specific manner in idiopathic scoliosis.

The paper identifies a homozygous KIF6 mutation in a child with neurocranial defects and intellectual disability, showing its role in ependymal cell cilia maintenance and neuro-cranial development through mouse and zebrafish models.