Chanjae Lee

The paper predicts the structure of the CPLANE complex and identifies novel interactors of Jbts17, revealing its role in ciliogenesis through in silico and experimental validation.

The paper reconstructs the protein interactome of the Last Eukaryotic Common Ancestor and identifies new human gene-disease associations for bone density and congenital birth defects.

The paper identifies two proteins, Ccdc78 and Ccdc33, at the distal tip of vertebrate motile cilia, showing they are essential for cilia organization, length regulation, and function.

The paper investigates the role of Lrrc56 in vertebrate multiciliated cells, showing it regulates outer dynein arm deployment through interaction with Odad3, linking LRRC56 mutations to primary ciliary dyskinesia.

This study identifies RSG1/CPLANE2 as a causative gene for human ciliopathy and shows its role in ciliary transition zone assembly.

The paper identifies de novo mutations contributing to meningomyelocele risk by analyzing trios and finding damaging mutations in 22.3% of cases.

The paper quantifies the relative rates of axonemal deployment for cilia beating machineries during the final stages of differentiation in Xenopus multiciliated cells.

The paper investigates how Arvcf catenin links subcellular actomyosin dynamics to tissue-scale force production during vertebrate convergent extension.

The paper investigates the role of Lrp2 in neural tube closure using mouse and Xenopus models, identifying its interaction with Shroom3 and Gipc1 and its role in apical constriction and planar cell polarity.

This study identifies TUBB8 as the molecular target of benzimidazoles, revealing their mechanism of vascular disruption and potential clinical applications.

The paper introduces DIF-FRAC, a label-free method to identify RNA-associated proteins in vertebrate tissues, revealing novel RAPs and RNA-enriched organelles.

The paper identifies a homozygous KIF6 mutation in a child with neurocranial defects and intellectual disability, showing its role in ependymal cell cilia maintenance and neuro-cranial development through mouse and zebrafish models.

The paper identifies phase-separated organelles called Dynein Assembly Particles in ciliated cells and links their dysfunction to a human genetic disease.

The paper synthesizes over 9,000 mass spectrometry experiments to create hu.MAP, a comprehensive human protein complex map with improved accuracy and coverage of disease-associated proteins.