Melissa A. Farrow

Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics

This study uses spatial transcriptomics to analyze gene expression in heart transplant recipients during rejection, identifying distinct transcriptomic profiles associated with different rejection types and outcomes.

Signal Strength Aware Latent Spaces Reveal Molecularly Distinct Substructures within Human Kidney Tissue

The paper introduces a method to uncover molecular substructures in human kidney tissue using signal strength-aware latent spaces, revealing previously unknown lipid species and biological subdivisions.

A Multimodal Imaging Pipeline for the Discovery of Molecular Markers of Cellular Neighborhoods

The paper develops a multimodal imaging pipeline to identify molecular markers of cellular neighborhoods in human kidney tissue by integrating imaging mass spectrometry and immunofluorescence data.

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

This paper describes the construction and usage of the Human Reference Atlas (HRA) v2.0, which integrates multiscale data across 36 organs and provides tools for analysis and visualization.

Consensus tissue domain detection in spatial -omics data using MILWRM

The paper introduces MILWRM, a tool for detecting tissue domains in spatial-omics data, and demonstrates its application in human colonic polyps and mouse brain slices.

A computational framework to explore cellular response mechanisms from multi-omics datasets

The paper introduces MAGINE, a framework for analyzing multi-omics time-course data to build mechanistic hypotheses of cellular responses to perturbations.