Author

Clement T. Y. Chan

University of North TexasORCID 0000-0001-7940-3459Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Fateme EsmailieiD· 1 shared L. Joseph Su· 1 shared Li LiiD· 1 shared Lin LiiD· 1 shared Miaomiao WangiD· 1 shared Miaomiao WangiD· 1 shared Nathalie T. NguyeniD· 1 shared Nhu Nguyen· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSynthetic Biology

Fateme EsmailieORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintJan 21, 2026

Engineered probiotics that sequester arsenite in a mouse gastrointestinal system

Nhu Nguyen, Miaomiao Wang, Sithembio S Msibi…·Clement T. Y. Chan

This paper engineers probiotics to sequester arsenite in the mouse gut, reducing its systemic absorption and demonstrating the feasibility of using living therapeutics for environmental toxin interception.

DOI 10.64898/2026.01.16.699961

mouseexperimental assay

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintDec 16, 2024

A genetic safeguard for eliminating target genes in synthetic probiotics in a gut environment

Nathalie T. Nguyen, Miaomiao Wang, Li Li, Clement T. Y. Chan

This paper introduces a genetic safeguard system for synthetic probiotics that degrades engineered genes without killing host microbes, demonstrating its feasibility in gut environments.

1 citation

E. coliCRISPR screen

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