Author

Nathalie T. Nguyen

Massachusetts General HospitalORCID 0009-0001-4282-103XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alba CarrerasiD· 1 shared Clement T. Y. ChaniD· 1 shared Frank SeeligeriD· 1 shared J. Keith JoungiD· 1 shared Jimmy A. GuoiD· 1 shared Jose Malagon-Lopez· 1 shared Kendell ClementiD· 1 shared Li LiiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Alba CarrerasORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintDec 16, 2024

A genetic safeguard for eliminating target genes in synthetic probiotics in a gut environment

Nathalie T. Nguyen, Miaomiao Wang, Li Li, Clement T. Y. Chan

This paper introduces a genetic safeguard system for synthetic probiotics that degrades engineered genes without killing host microbes, demonstrating its feasibility in gut environments.

1 citation

E. coliCRISPR screen

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Molecular BiologyNaturePeer-reviewedSep 1, 2018

In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations

Pınar Akçakaya, Maggie L. Bobbin, Jimmy A. Guo…·J. Keith Joung

The paper introduces VIVO, a method to detect off-target mutations from in vivo CRISPR-Cas editing, showing that well-designed gRNAs can edit efficiently without detectable off-targets.

322 citationstop 1%

humanCRISPR screen

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