Li Li

FORGE converts RNA geometry into interpretable descriptors to identify native nucleotides and predict base-pair states, showing high accuracy and separable properties in RNA structure analysis.

This study identifies C1R as a molecular link between coronary artery disease and dementia through proteogenomic analysis of circulating proteins and genetic causal-inference.

HARMONY harmonizes neuroimaging data from multiple cohorts to study brain-behavior associations in anxious misery disorders, showing increased statistical power in pooled analyses.

Navigo models mouse embryogenesis to predict cell fates and disease by learning developmental trajectories from scRNA-seq data.

The paper identifies a widespread transcript leakage issue in spatial transcriptomics and introduces DeLeakage, a Bayesian method that improves data cleaning and cell-type annotation.

This study identifies SigH as a key regulator of intrinsic antibiotic resistance in Mycobacterium abscessus through transcriptomic analysis and genetic complementation.

This paper identifies two circular RNA aptamers that act as sub-stoichiometric chaperones to suppress pathological TDP-43 condensation and rescue splicing and motor dysfunction in vivo.

This study investigates miR-128's role in regulating vascular remodeling in SHRs through PPAR-γ and the TLR4/NF-κB pathway, showing that RDN restores miR-128 and improves vascular function.

The paper presents a dataset linking two-photon calcium imaging with auditory behavior in mice, validated for use in decoding algorithms and computational models.

This study evaluates clinically relevant vaccine adjuvants using a human immune organoid model, identifying AddaSO3 as consistently effective across early and prolonged immune response phases.

The paper presents a dataset of neural spiking activity and licking behavior in thirsty mice, enabling precise spike-to-event mapping and benchmarking for neural decoding algorithms.

This paper introduces a genetic safeguard system for synthetic probiotics that degrades engineered genes without killing host microbes, demonstrating its feasibility in gut environments.