Huaitao Cheng

The paper analyzes subclonal gene dosage effects in cancer using DNTR-seq, finding additive and compensatory transcriptional impacts and identifying transient clonality in ovarian and soft tissue sarcomas.

This study shows ALK R1275Q mutation sustains an immature SCP-like cell state during sympathoadrenal commitment, increasing susceptibility to MYCN-driven neuroblastoma initiation.

This study uses allele-resolved single-cell multi-omics to reveal the dynamics and transcriptional kinetics of X-chromosome upregulation in mouse development.

Smart3-ATAC enables joint analysis of mRNA and chromatin accessibility in single cells with higher yield than existing droplet multiome methods.

DNTR-seq jointly profiles whole genome and mRNA in single cells, enabling subclone detection and gene editing analysis in leukemia samples with high sensitivity and low bias.

This paper investigates DEF6's role in forming prion-like aggregates that trap P-body components and alters its localization through phosphorylation-induced conformational changes.

The paper identifies the N-terminal 45 amino acids of DEF6 as necessary and sufficient for its colocalization with DCP1 in P-bodies, challenging the role of the coiled coil domain.