Nathanael Andrews

This paper evaluates isoform-level resolution in single-cell CRISPR screens using long-read sequencing, finding that it captures splicing changes missed by gene-level analysis.

The paper integrates multi-omic QTLs and predictive models to identify regulatory variants in CD4+ T cells and their role in immune-related GWAS loci.

CRISPore-seq combines CRISPR perturbations with long-read transcriptomics to detect alternative splicing changes, revealing that exon skipping is common and linked to RNA-binding protein perturbations.

This study uses allele-resolved single-cell multi-omics to reveal the dynamics and transcriptional kinetics of X-chromosome upregulation in mouse development.

Smart3-ATAC enables joint analysis of mRNA and chromatin accessibility in single cells with higher yield than existing droplet multiome methods.

DNTR-seq jointly profiles whole genome and mRNA in single cells, enabling subclone detection and gene editing analysis in leukemia samples with high sensitivity and low bias.

The paper develops CIM-seq to profile cell interactions in mouse intestinal tissues, revealing distinct stem cell niche architectures in small intestine and colon.