Author

Regine L. Mühlfriedel

University of TübingenORCID 0000-0001-7955-1654Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Developmental Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

Mathias W. SeeligeriD· 5 shared Alexander GünteriD· 3 shared Blanca Arango‐GonzáleziD· 2 shared Bowen CaoiD· 2 shared Christine Henes· 2 shared Ellen KilgeriD· 2 shared Marius UeffingiD· 2 shared Sylvia Bolz· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersNeuroscience

Mathias W. SeeligerORCID

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5 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 21, 2026

On the location of a "central retina" in mice

Alexander Günter, Regine L. Mühlfriedel, Mathias W. Seeliger

This study identifies the S-opsin transitional zone in mice as the functional 'central retina' by comparing it to the visual streak in diurnal rodents.

DOI 10.64898/2026.04.16.718979

mouse

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NeurosciencebioRxivPreprintJun 25, 2025

Ocular delivery of different VCP inhibitory formulations prevents retinal degeneration in rhodopsin 255 isoleucine deletion mice

Bowen Cao, Regine L. Mühlfriedel, Merve Sen…·Blanca Arango‐González

This study evaluates three VCP-targeted therapies in a mouse model of retinitis pigmentosa, finding that nanocarrier-encapsulated ML240 provides the best protection against photoreceptor degeneration.

DOI 10.1101/2025.06.25.661245

mouseexperimental assay

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Cell BiologyFrontiers in MedicinePeer-reviewedApr 22, 2025

A remarkable degree of conformance between the visual streak of the Mongolian gerbil and the human central retina

Alexander Günter, Mohamed Ali Jarboui, Regine Mühlfriedel, Mathias W. Seeliger

The paper compares the retinal structure of the Mongolian gerbil's visual streak to the human macula, finding similar features that suggest the gerbil as a model for studying the human central retina.

1 citation

mouseimaging

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PathologybioRxivPreprintAug 29, 2024

Autosomal dominant Retinitis Pigmentosa caused by the rhodopsin isoleucine 255 deletion features rapid neuroretinal degeneration, decreased synaptic connectivity, and neuroinflammation.

Bowen Cao, Yu Zhu, Alexander Günter…·Marius Ueffing

This paper introduces a novel mouse model of dominant retinitis pigmentosa caused by the RHO{Delta}I255 mutation, showing rapid photoreceptor degeneration, neuroinflammation, and disrupted neuronal connectivity.

4 citations

mouseexperimental assay

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Developmental BiologyCirculation ResearchPeer-reviewedJul 14, 2022

Mural cell SRF controls pericyte migration, vessel patterning and blood flow

Michael M. Orlich, Rodrigo Diéguez‐Hurtado, Regine L. Mühlfriedel…·Alfred Nordheim

This study investigates the role of SRF in mural cells, showing its importance in pericyte migration, vessel patterning, and blood flow during development and disease.

43 citations

mouseexperimental assay

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