Mathias W. Seeliger

This study identifies the S-opsin transitional zone in mice as the functional 'central retina' by comparing it to the visual streak in diurnal rodents.

This study investigates the role of PPARs and PGC-1α in photoreceptor neuroprotection in rd1 mouse model of retinal degeneration, finding that their activation reduces photoreceptor death and PARP activity.

This study evaluates three VCP-targeted therapies in a mouse model of retinitis pigmentosa, finding that nanocarrier-encapsulated ML240 provides the best protection against photoreceptor degeneration.

The paper compares the retinal structure of the Mongolian gerbil's visual streak to the human macula, finding similar features that suggest the gerbil as a model for studying the human central retina.

This paper introduces a novel mouse model of dominant retinitis pigmentosa caused by the RHO{Delta}I255 mutation, showing rapid photoreceptor degeneration, neuroinflammation, and disrupted neuronal connectivity.

This study investigates the role of calcium signaling in photoreceptor cell death in IRD using mouse models and identifies calpain-2 as a key contributor to degeneration.

This study investigates the role of SRF in mural cells, showing its importance in pericyte migration, vessel patterning, and blood flow during development and disease.

This study investigates the role of 2δ-3 in mouse retinal ganglion cells, finding subtle changes in visual responses under low and moderate light levels but normal optokinetic reflexes.