Richard D. Unwin

stably (Python) applies error-controlled stability selection to DIA-NN output; its 17-protein pancreatic cancer panel reached held-out AUC 0.93 versus 0.82 for a published two-protein panel rescored on the same data.

This paper refines spectral libraries for DIA proteomics by removing poor quantitative peptides, improving quantification accuracy and reducing noise.

The paper measures brain urea levels in post-mortem tissue from FTD and ALS patients, finding elevated urea in both diseases and suggesting a shared pathogenic mechanism.

This paper develops CTx001, a gene therapy expressing mini-CR1, which reduces MAC formation in a rat model of geographic atrophy.

The paper uses long-read RNA-seq to study splicing changes in an Alzheimer's mouse model, identifying novel transcript isoforms and alternative splicing events in response to amyloid-beta.

This study identifies region-specific protein expression changes in human Alzheimer’s brains, revealing disease severity gradients and protective profiles in the cerebellum.