Cell BiologyNature CommunicationsPeer-reviewed
SON-dependent nuclear speckle rejuvenation alleviates proteinopathies
William A. Dion, Yuren Tao, Maci Chambers…·Bokai Zhu
This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.