SON-dependent nuclear speckle rejuvenation alleviates proteinopathies
William A. Dion, Yuren Tao, Maci Chambers, Shanshan Zhao, Riley K. Arbuckle, Michelle Sun, Syeda Kubra, Matthew A. Schaich, Yuhang Nie, Megan Ye, Imran Jamal, Mads Breum Larsen, Daniel P. Camarco, Eleanor Ickes, Haokun H. Wang, , Bokai Zhu
This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.
Nature Communications · Aug 5, 2025Peer-reviewedCell Biology